And four equals one: Presenilin takes the -secretase role by itself
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منابع مشابه
And four equals one: presenilin takes the gamma-secretase role by itself.
T he amyloid precursor protein (APP) is the precursor to the amyloid β-protein (Aβ), which is the major constituent of amyloid plaques found in brains of individuals with Alzheimer’s disease (AD). Because amyloid (senile) plaques are one of the pathological hallmarks of AD, processing of APP and generation of Aβ from APP have been areas of intense study. Cloning of the APP cDNA in 1987 led to a...
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Presenilins (PS) are the catalytic components of gamma-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins. Specially relevant is the gamma-secretase-dependent cleavage of the beta-amyloid precursor protein (APP) since generates the beta-amyloid (Abeta) peptides that aggregate and accumulate in the brain of Alzheimer's diseas...
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T effort to solve Alzheimer’s disease (AD) has led to a salutary intersection between the desire to prevent a major health problem and the fundamental study of membrane protein biology. It has become apparent in the last few years that a compelling strategy to treat and prevent AD may involve understanding how certain integral membrane proteins undergo unusual proteolytic cleavages within their...
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c-Secretase modulators, or GSMs, which reduce the production of Ab42, have emerged as a promising class of compounds for the treatment of Alzheimer’s disease (AD). The target and mechanism of action of GSMs have been controversial as of late, with some evidence suggesting that GSMs function by binding the substrate, amyloid precursor protein (APP), and others claiming action through direct modu...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1016284108